- Clinch River Steam Plant, in Russell County
- Parkey Cemetery, in Lee County
- Poor Branch, a stream in Carroll County
- Poplar Hollow, a valley in Russell County
- Possum Hollow, a valley in Tazewell County
- Roberts Creek, a stream in Scott County
- Robinson Ridge, a ridge in Russell County
- Sharp Cemetery, in Carroll County
- Short Hollow, a valley in Washington County
- Speer Cemetery, in Scott County
- Spring Ridge, a ridge in Dickenson County
- Spruce Lick Branch, a stream in Scott County
- Stagger Hollow, a valley in Washington County
- Stallard Ford, in Lee County
- Stanley Valley, a valley in Scott County
- State Line Hollow, a valley in Buchanan County
- Stephen Cemetery, in Dickenson County
- Stormy Gap, a gap in Wise County
- Three Forks, in Wise County
- Tip Top Gap, a gap in Lee County
- Trace Fork School, a school in Wise County
- Trace Hollow, a valley in Buchanan County
- Trout Dale Cemetery, in Grayson County
- Turkey, a depression in Lee County
- Turkey Pen Ridge, a ridge in Buchanan County
- Upper Skegg Fork, a stream in Dickenson County
- Vanderventer Cemetery, in Lee County
- Vaughn Cemetery, in Scott County
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- Watson Cemetery, in Scott County
- Weber City Elementary School, a school in Scott County
- Whiterock Cove, a valley in Washington County
- Whitewood School (historical), a school in Buchanan County
- Whitt Cemetery, in Buchanan County
- Wilburn Cemetery, in Tazewell County
- Wildcat Spur, a ridge in Dickenson County
- Wilkinson Cemetery, in Carroll County
- Williams Cemetery, in Russell County
- Williams Cove, a valley in Wise County
- Willis Cemetery, in Dickenson County
- Willow Hill Cemetery, in Carroll County
- Winding Ridge, a ridge in Buchanan County
- Wisler Cemetery, in Carroll County
- Wolf Creek, a stream in Washington County
- Wolfe Cemetery, in Scott County
- Wolfpen Hollow, a valley in Russell County
- Wooten Gap, a gap in Washington County
- Wrights Pasture, a plain in Lee County
- Wysor Valley, a valley in Russell County
- Wythe County Community Hospital, a hospital in Wythe County
- Wytheville National Fish Hatchery Number 1, in Wythe County
- Yeary Cemetery, in Lee County
- York School (historical), a school in Lee County
- Young Cemetery, in Grayson County
- Yowling Hollow, a valley in Dickenson County
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