- Blackey, in Buchanan County
- Fort Chiswell Magisterial District, in Wythe County
- Harman Junction, in Buchanan County
- Hazel, in Russell County
- Jacksons Store, in Russell County
- Jonesville Camp Ground, in Lee County
- Josephine, in Wise County
- Kegleys, in Wythe County
- Kenady Magisterial District, in Dickenson County
- Kent, in Wythe County
- Kent Junction, in Wise County
- Kermit, in Scott County
- Kesterson Mill, in Lee County
- Ketrontown, in Scott County
- Keywood, in Washington County
- Lanes Store, in Wise County
- Lano, in Scott County
- Laswell, in Wythe County
- Laurel, in Wise County
- Laurel (historical), in Russell County
- Laurel Grove, in Wise County
- Laureldale, in Washington County
- Lebanon, population 3,163, in Russell County
- Leck, in Dickenson County
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- Lick Skillet, in Smyth County
- Lindell, in Washington County
- Linden, in Wise County
- Lipps, in Wise County
- Little Duck, in Scott County
- Little Stony Creek, a stream in Scott County
- Little Town, in Tazewell County
- Litz, in Washington County
- Lockhart Flats, in Dickenson County
- Locust Hill, in Wythe County
- Locust Hill School (historical), a school in Wythe County
- Lonesome (historical), in Wise County
- Long Branch, a stream in Dickenson County
- Longbottom, in Buchanan County
- Longfork, in Dickenson County
- Longhollow (historical), in Smyth County
- Looney Branch, a stream in Buchanan County
- Looney Creek, a stream in Wise County
- Looney Creek School, a school in Buchanan County
- Looney Fork, a stream in Buchanan County
- Loop Creek, a stream in Russell County
- Lost Creek, a stream in Wise County
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