- Bolton, in Russell County
- Bush Mill, in Scott County
- Calvin, in Lee County
- Cannady, in Buchanan County
- Carnot, in Bland County
- Carterton, in Russell County
- Cedar Bluff, population 1,085, in Tazewell County
- Crabtree School, a school in Russell County
- Crackers Neck, in Scott County
- Cranes Nest, in Wise County
- Cranes Nest River, a stream in Dickenson County
- Creswell, in Russell County
- Criggers, in Tazewell County
- Cripple Creek, in Wythe County
- Crowgeys, in Wythe County
- Daniel Boone Trail, in Lee County
- Darnell Town, in Lee County
- Darwin, in Dickenson County
- Davenport, in Buchanan County
- Daw, in Russell County
- Dean Branch, a stream in Scott County
- Dean School, a school in Lee County
- Deans Store, in Scott County
- Deavers Branch, a stream in Bland County
- Debusk (historical), in Dickenson County
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- Deel, in Buchanan County
- Deep Spring School (historical), a school in Lee County
- Deep Springs, in Lee County
- Gibson Mill, in Lee County
- Grant, in Grayson County
- Little Rockhouse Branch, a stream in Dickenson County
- Lodi, in Washington County
- Masons Store (historical), in Russell County
- Mayflower, in Lee County
- Mitchell School (historical), a school in Tazewell County
- Mount Bethel School, a school in Carroll County
- Mount Carmel, in Smyth County
- Mount Carmel School (historical), a school in Grayson County
- Stratton, in Dickenson County
- Sun, in Russell County
- Wells, in Wise County
- West Dante, in Dickenson County
- West Galax, in City of Galax
- West Graham, in Tazewell County
- West Piney, in Wythe County
- West Raven, in Russell County
- West Wytheville Magisterial District, in Wythe County
- Yuma, in Scott County
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